Recent studies showed that poor lifestyle in both mothers and fathers of reproductive age not only harms their health but also initiates a vicious cycle of metabolic dysfunction, propagating risk to offspring via epigenetic and metabolic mechanisms. I demonstrated that maternal exercise during pregnancy is a promising method as a “preemptive medical treatment” to prevent the transmission obesity and diabetes from the current generation to the next generation. I identified that placenta-derived proteins are important factors that transmit the beneficial effects of exercise to offspring. We are comprehensively analyzing; 1) boosting nutrients to enhance the benefits of maternal exercise, 2) maternal organs and mediators that activates exercise-placenta signaling axis, 3) physiological parameters that can quantify placental functions. My hypothesis is that the placenta is a transducer that conveys maternal information to their children. To prevent lifestyle-related diseases and congenital diseases in the next generation, I try to utilize placental function with the combination of molecular genetics, informatics, devices, and psychology in TI-FRIS. I would like to translate my findings from highly specialized bench-side to daily life-side through the use of cutting-edge technology and clinical insights.