January 15, 2026
The 56th TI-FRIS Hub Meeting / 72nd FRIS Hub Meeting (Hybrid event)
TI-FRIS Hub Meetings are held once a month at Tohoku University to foster researchers who understand and can utilize the importance of interdisciplinary research across disciplines and institutions.
Common sense and way of thinking cannot be expected among researchers in different fields. The audience is encouraged to ask questions during the presentation to discuss and deepen their understanding. Please participate actively.
・Date & Time: Every Friday of the month except August (16:00-17:00)
・Target Audience: TI-FRIS Fellows, researchers and students from TI-FRIS participating institutions
The 56th TI-FRIS Hub Meeting (jointly held with the 72nd FRIS Hub Meeting)
Date and Time ：
Friday, January 23, 2026, 16:00 to 17:00
Event Format：
Hybrid (Frontier Research Institute for Interdisciplinary Sciences Seminar room and Online)
*The following persons are eligible to participate
1. Hub Meeting members
Participants targeted for presentation and archived viewing
- FRIS faculty members
- TI-FRIS Fellows
2. Observers
The following participants interested in the Hub Meeting (may also participate in questions and discussions)
The following participants interested in the Hub Meeting (may also participate in questions and discussions)
- Tohoku University DIARE Students
- Staff and students of Tohoku University
- Staff and students of TI-FRIS participating universities
- TI-FRIS officials (committee members, etc.)
- Fellows of “Strategic Professional Development Program for Young Researchers”
- Those approved by the Director of FRIS / TI-FRIS Program Manager
Presenter：
Asst. Prof., MARAHLEH Aseel ( Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University/Advanced Basic Science）
Presentation Title：
Beyond Density: Biomarkers for Dynamic Bone Diagnostics
Abstract：
Metabolic diseases, often lead to irreversible bone damage before diagnosis. Skeletal fragility becomes visible long after the underlying molecular systems have been stressed. Our research addresses a critical gap: Can we detect the earliest signals of skeletal metabolic disease long before structural changes occur?
Current diagnostics focus on structure (density) and a few circulating markers, only reporting damage that has already happened. This fails in metabolic diseases where fracture risk is high despite "normal" bone density. This gap suggests that we are not yet measuring the layers of biology where the earliest signals of disease reside.
My work treats bone as a dynamic metabolic sensor encoding early stress in its molecular language. By tracking how diet modulates the cellular proteome and governs RNA translation, we aim to uncover molecular ""early-warning signatures"" of fragility. Using advanced omics technologies, our vision is to shift diagnostics from static snapshots to dynamic, predictive biomarkers and establish a foundational molecular framework for understanding metabolic bone fragility.
Current diagnostics focus on structure (density) and a few circulating markers, only reporting damage that has already happened. This fails in metabolic diseases where fracture risk is high despite "normal" bone density. This gap suggests that we are not yet measuring the layers of biology where the earliest signals of disease reside.
My work treats bone as a dynamic metabolic sensor encoding early stress in its molecular language. By tracking how diet modulates the cellular proteome and governs RNA translation, we aim to uncover molecular ""early-warning signatures"" of fragility. Using advanced omics technologies, our vision is to shift diagnostics from static snapshots to dynamic, predictive biomarkers and establish a foundational molecular framework for understanding metabolic bone fragility.
